LYMPHOID NEOPLASIA Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
نویسندگان
چکیده
1Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA; 2Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA; 3Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, P.R. China; and 4SAIC-Frederick, Laboratory of Experimental Immunology, National Cancer Institute–Frederick, Frederick, MD
منابع مشابه
Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia.
The natural killer (NK) type of aggressive large granular lymphocytic (LGL) leukemia is a fatal illness that pursues a rapid clinical course. There are no effective therapies for this illness, and pathogenetic mechanisms remain undefined. Here we report that the survivin was highly expressed in both aggressive and chronic leukemic NK cells but not in normal NK cells. In vitro treatment of human...
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BACKGROUND The 2008 World Health Organization (WHO) classification distinguishes three entities among the large granular lymphocytic leukemia (LGL leukemia): T-cell LGL leukemia (T-LGL leukemia), aggressive natural killer (NK) cell leukemia, and chronic NK lymphoproliferative disorders (LPD), the later considered as a provisional entity. Only a few and small cohorts of chronic NK LPD have been ...
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